On Tableau Server 2022.1.5 with a multi-node configuration, extracts would fail to refresh and it would not be possible to publish data sources. The extract refresh error would display "java.lang.RuntimeException: encountered issue for storing separate reduced tdsx for site: 'X' datasource: 'XXXXX'".  An "Internal Server Error" would occur trying to publish a datasource to Tableau Server. For more information, see this KB article.